|
KMID : 0981820080280030201
|
|
Korean Journal of Laboratory Medicine
2008 Volume.28 No. 3 p.201 ~ p.206
|
|
|
Clinical Utility of Serum Pepsinogen Levels as a Screening Test of Atrophic Gastritis
|
|
Chae Hyo-Jin
Lee Je-Hoon
Kim Myung-Shin
Lim Ji-Hyang
Kim Yong-Goo
Han Kyung-Ja
Kang Chang-Suk
Kim Jin-Il
Park Soo-Heon
Shim Sang-In
|
|
|
Abstract
|
|
|
Background: Atrophic gastritis is a well known risk factor for gastric adenocarcinoma. Its confirmatory diagnosis requires histology via endoscopy, which is an invasive method; therefore, periodic follow up evaluation as a screening method is difficult to perform. We evaluated the clinical utility of serum pepsinogens (PG) as a biomarker for screening of atrophic gastritis.
Methods: The study population consisted of 130 selected dyspeptic patients (M:F=52:78; age, 16-105 yrs; mean age, 50.8 yrs) who had undergone a diagnostic endoscopy. The serum pepsinogen test was performed by a latex turbidimetric immunoassay method (HBI, Korea) using Toshiba-200FR automatic analyzer. The PGI, II level and PGI:PGII ratio of non-atrophic gastritis group were compared with those of atrophic gastritis group, and a correlation with Helicobacter pylori infection was examined. Cut-off points for screening of atrophic gastritis were determined.
Results: The mean serum concentration of PGI showed a decline from normal (60.7 ng/mL), nonatrophic
gastritis (54.2 ng/mL), and atrophic gastritis (51.8 ng/mL) to gastric adenocarcinoma (32.6ng/mL). The mean ratio of PGI:PGII was lower in atrophic gastritis (3.2) compared to non-atrophic gastritis (4.7) (P=0.021). In patients with H. pylori infection, the mean serum PGII level was higher and the PGI:PGII ratio was lower than those in patients without H. pylori infection, and the differences were statistically significant. For screening of atrophic gastritis, the best cut-off point of PGI:PGII ratio was 4, with a sensitivity of 82.6% and specificity of 91.7%.
Conclusions: The serum pepsinogen test is a useful biomarker for screening of atrophic gastritis, a well-known precancerous lesion of gastric adenocarcinoma. Measuring both pepsinogen I and II concentrations simultaneously to obtain pepsinogen I/II ratio provides a clinically useful information for the detection of atrophic gastritis.
|
|
|
KEYWORD
|
|
|
Atrophic gastritis, Pepsinogen, Pepsinogen I/II ratio, Gastric cancer
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
  
|
|